Across TCGA patient cohorts, NYX mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NYX-associated genes across cancer lineages are Annexin-1, C-Raf_pS338, and Chk1. Each is linked with NYX in more than 1 cancer types. Because this analysis shows association rather than direction, both NYX-to-partner and partner-to-NYX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NYX→partner) and Y-score (partner→NYX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.960	+2.827	.001	.035	3	1
UCEC	C-Raf_pS338 →	-0.114	-3.000	.015	.037	3	1
LUSC	Chk1 →	+0.239	+2.816	.034	.036	1	2
UCEC	Notch1 →	+0.169	+3.000	.038	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

NYX survival (RNA) · tumor vs normal (RNA) · all NYX data types