Across TCGA cell cohorts, NYX mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NYX-associated genes across cancer lineages are GIMAP4, CNMD, and GABRA6. Each is linked with NYX in more than 1 cancer types. Because this analysis shows association rather than direction, both NYX-to-partner and partner-to-NYX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NYX→partner) and Y-score (partner→NYX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GIMAP4 →	+0.036	+3.900	.002	.006	3	1
LUNG_NSCLC_LUAD	CNMD →	+0.279	+3.807	.001	.007	3	1
LUNG_NSCLC_LUAD	GABRA6 →	+0.066	+4.189	<.001	.002	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.013	+4.078	<.001	.009	3	1
LUNG_SCLC	OR13C4 →	+0.165	+5.029	<.001	.006	3	1
OVARY	SULT6B1 →	+0.091	+4.228	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

NYX survival (RNA) · tumor vs normal (RNA) · all NYX data types