Across TCGA cell cohorts, NYX mutation is significantly associated with the mutation status of many other genes, with 1,880 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NYX-associated genes across cancer lineages are NR4A2, RBM47, and HS6ST2. Each is linked with NYX in more than 3 cancer types. Because this analysis shows association rather than direction, both NYX-to-partner and partner-to-NYX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NYX→partner) and Y-score (partner→NYX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NR4A2 →	+3.313	+3.430	.005	.005	1	4
LUNG_NSCLC_LUAD	RBM47 →	+5.000	+4.187	.008	.008	1	4
BLOOD_Leukemia	HS6ST2 →	+4.635	+4.145	.001	.001	1	4
LUNG_NSCLC_LUAD	PPARD →	+5.000	+4.187	.008	.008	1	4
LUNG_SCLC	ITGB1 →	+5.066	+4.502	.007	.007	1	4
BLOOD_Leukemia	ANKLE1 →	+5.050	+4.000	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,880 associations by consensus.

Exploration

NYX survival (RNA) · tumor vs normal (RNA) · all NYX data types