Across TCGA pan-cancer cohorts, NYNRIN mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NYNRIN data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NYNRIN mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NYNRIN expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where NYNRIN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	1.000	0.486	<.001	21	view →
LUAD	DFS	Quartile	II,III,IV	0.745	0.991	.015	13	view →
HNSC	OS	Median	All	0.793	0.567	.030	5	view →
PDAC	OS	Median	All	0.761	1.000	.008	5	view →
UCEC	DFS	Quartile	All	0.796	0.963	.046	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: NYNRIN tumor-vs-normal RNA expression · all NYNRIN data types