NYAP1

Across TCGA patient cohorts, NYAP1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NYAP1-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and eEF2. Each is linked with NYAP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NYAP1-to-partner and partner-to-NYAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by NYAP1-low versus NYAP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NYAP1→partner) and Y-score (partner→NYAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.284	+2.815	.037	.036	3	4
COAD	Caspase-7-cleavedD198 →	+1.267	+2.824	.003	.034	3	2
UCEC	eEF2 →	+0.409	+2.700	.011	.006	3	2
SKCM	Rab25 →	-0.216	-2.442	.028	.017	3	2
UCEC	Di-Ras3 →	-0.198	-2.700	.003	.006	3	2
SKCM	E-Cadherin →	-0.856	-2.000	.012	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

PCNA by NYAP1 expression — COAD

Explore this box plot interactively →