NXT2

Across TCGA patient cohorts, NXT2 mutation is significantly associated with the RNA expression of many other genes, with 5,066 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NXT2-associated genes across cancer lineages are RN7SL134P, ATXN3L, and MIR4510. Each is linked with NXT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXT2-to-partner and partner-to-NXT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by NXT2-low versus NXT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXT2→partner) and Y-score (partner→NXT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL134P →	+0.096	+1.883	.001	.004	3	2
COAD	ATXN3L →	+0.169	+5.721	<.001	.001	3	2
CESC	MIR4510 →	+0.297	+5.342	<.001	.002	3	2
UCEC	LINC01072 →	+0.099	+2.029	<.001	.001	3	2
UCEC	RNA5SP413 →	+0.879	+1.488	<.001	.009	3	2
UCEC	ADM →	+0.736	+1.726	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,066 associations by consensus.

RN7SL134P by NXT2 expression — UCEC

Explore this box plot interactively →