NXT2

Across TCGA patient cohorts, NXT2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NXT2-associated genes across cancer lineages are STAT3_pY705, ASNS, and Cyclin-D1. Each is linked with NXT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXT2-to-partner and partner-to-NXT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by NXT2-low versus NXT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXT2→partner) and Y-score (partner→NXT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.451	-2.321	<.001	.001	3	2
UCEC	ASNS →	+0.403	+2.321	.001	.005	3	2
UCEC	Cyclin-D1 →	+0.137	+2.459	.018	.018	3	2
UCEC	eEF2 →	+0.347	+2.459	.007	.018	3	1
UCEC	EGFR_pY1068 →	-0.246	-2.459	.006	.018	3	1
UCEC	eIF4G →	+0.281	+1.925	.012	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

STAT3_pY705 by NXT2 expression — UCEC

Explore this box plot interactively →