NXPH4

Across TCGA patient cohorts, NXPH4 mutation is significantly associated with the RNA expression of many other genes, with 149 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NXPH4-associated genes across cancer lineages are SMSP1, RPL7P5, and RNA5SP205. Each is linked with NXPH4 in more than 2 cancer types. Because this analysis shows association rather than direction, both NXPH4-to-partner and partner-to-NXPH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMSP1 grouped by NXPH4-low versus NXPH4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXPH4→partner) and Y-score (partner→NXPH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SMSP1 →	+0.060	+3.838	<.001	.006	3	3
SKCM	RPL7P5 →	+0.114	+4.114	<.001	.005	3	2
UCEC	RNA5SP205 →	+0.236	+3.630	.001	.003	3	2
UCEC	HMGN2P31 →	+0.327	+3.012	.009	.004	3	2
SKCM	RNU6-27P →	+0.228	+4.614	<.001	.006	3	2
SKCM	MIR4488 →	+0.429	+4.614	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 149 associations by consensus.

SMSP1 by NXPH4 expression — SKCM

Explore this box plot interactively →