NXPH3

Across TCGA patient cohorts, NXPH3 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NXPH3-associated genes across cancer lineages are A-Raf_pS299, MEK1, and p62 Lck ligand. Each is linked with NXPH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXPH3-to-partner and partner-to-NXPH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by NXPH3-low versus NXPH3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXPH3→partner) and Y-score (partner→NXPH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.177	-3.000	.001	.036	3	1
UCEC	MEK1 →	+0.502	+3.169	.003	.019	3	1
UCEC	p62 Lck ligand →	+0.484	+2.584	.001	.011	3	1
UCEC	AMPK_pT172 →	+0.420	+1.887	.028	.031	3	1
UCEC	Raptor →	-0.149	-3.000	.035	.036	3	1
UCEC	XBP1 →	-0.201	-2.308	.002	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

A-Raf_pS299 by NXPH3 expression — UCEC

Explore this box plot interactively →