NXPH3

Across TCGA cell cohorts, NXPH3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NXPH3-associated genes across cancer lineages are FCN2, SCGB3A2, and BPIFA1. Each is linked with NXPH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXPH3-to-partner and partner-to-NXPH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN2 grouped by NXPH3-low versus NXPH3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXPH3→partner) and Y-score (partner→NXPH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FCN2 →	+0.039	+4.415	<.001	.007	3	1
LARGE_INTESTINE	SCGB3A2 →	+0.384	+4.095	<.001	.009	3	1
LARGE_INTESTINE	BPIFA1 →	+0.287	+4.273	<.001	.006	3	1
LARGE_INTESTINE	MAGEB3 →	+0.055	+4.467	<.001	.004	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.015	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

FCN2 by NXPH3 expression — LARGE_INTESTINE

Explore this box plot interactively →