NXPH2

Across TCGA pan-cancer cohorts, NXPH2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NXPH2 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher NXPH2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated NXPH2 expression acts as an unfavorable survival marker.

ESCA, LUSC, and LIHC are the cancer types where NXPH2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	All	0.080	0.533	<.001	18	view →
LUSC	OS	Median	All	0.173	0.724	.012	6	view →
LIHC	OS	Median	All	0.025	0.775	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NXPH2–ESCA (DFS)

Open the ESCA breakdown →