NXPH2

Across TCGA patient cohorts, NXPH2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NXPH2-associated genes across cancer lineages are ERK2, 4E-BP1, and Ku80. Each is linked with NXPH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NXPH2-to-partner and partner-to-NXPH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by NXPH2-low versus NXPH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXPH2→partner) and Y-score (partner→NXPH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.239	+2.321	.007	.034	3	2
UCEC	4E-BP1 →	+0.366	+2.837	.003	.035	3	2
LUSC	Ku80 →	+0.449	+2.197	.005	.033	3	1
LUSC	VHL →	+0.896	+2.179	.026	.035	2	2
LUSC	Bcl-xL →	-0.177	-3.312	.015	.010	3	1
UCEC	Cyclin-B1 →	+0.695	+2.584	.007	.011	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ERK2 by NXPH2 expression — UCEC

Explore this box plot interactively →