NXPH2

Across TCGA cell cohorts, NXPH2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NXPH2-associated genes across cancer lineages are MAGEB5, PTCHD1, and TFDP3. Each is linked with NXPH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXPH2-to-partner and partner-to-NXPH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by NXPH2-low versus NXPH2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXPH2→partner) and Y-score (partner→NXPH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LARGE_INTESTINE	PTCHD1 →	+0.262	+3.813	.006	.003	3	1
LARGE_INTESTINE	TFDP3 →	+0.020	+3.196	.001	.007	3	1
LARGE_INTESTINE	DAZ2 →	+0.170	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	RBMY1J →	+0.006	+4.022	<.001	.006	3	1
LARGE_INTESTINE	C2orf73 →	+0.064	+3.443	.003	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MAGEB5 by NXPH2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →