NXPH1

Across TCGA pan-cancer cohorts, NXPH1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NXPH1 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher NXPH1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NXPH1 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

LUSC, SKCM, and SARC are the cancer types where NXPH1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	III,IV	0.057	0.691	<.001	34	view →
SKCM	DFS	Median	II,III,IV	0.594	0.212	.010	8	view →
SARC	DFS	Median	All	0.109	0.591	.020	6	view →
HNSC	DFS	Median	III,IV	0.352	0.665	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NXPH1–LUSC (OS)

Open the LUSC breakdown →