NXPH1

Across TCGA patient cohorts, NXPH1 mutation is significantly associated with the RNA expression of many other genes, with 4,998 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NXPH1-associated genes across cancer lineages are RNU6-618P, GUCA1B, and RNU6-1187P. Each is linked with NXPH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NXPH1-to-partner and partner-to-NXPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-618P grouped by NXPH1-low versus NXPH1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXPH1→partner) and Y-score (partner→NXPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-618P →	+0.385	+3.790	<.001	.001	3	3
UCEC	GUCA1B →	+0.529	+2.606	<.001	<.001	3	3
LUAD	RNU6-1187P →	+0.368	+3.123	.005	.007	3	2
CESC	RNU6-220P →	+0.195	+4.342	<.001	.007	3	2
CESC	RNA5SP198 →	+0.184	+4.144	<.001	.009	3	2
CESC	RBISP1 →	+0.130	+4.010	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,998 associations by consensus.

RNU6-618P by NXPH1 expression — LUAD

Explore this box plot interactively →