NXPH1

Across TCGA patient cohorts, NXPH1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NXPH1-associated genes across cancer lineages are 14-3-3_beta, EGFR, and STAT3_pY705. Each is linked with NXPH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXPH1-to-partner and partner-to-NXPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by NXPH1-low versus NXPH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXPH1→partner) and Y-score (partner→NXPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.071	-2.295	.044	.033	3	2
SKCM	EGFR →	-0.190	-3.000	.019	.034	3	2
UCEC	STAT3_pY705 →	-0.432	-1.838	<.001	.007	3	2
UCEC	Tuberin →	+0.403	+3.807	<.001	<.001	3	2
UCEC	Bcl-2 →	-0.322	-1.980	.008	.030	3	2
UCEC	C-Raf →	+0.141	+1.584	.005	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

14-3-3_beta by NXPH1 expression — UCEC

Explore this box plot interactively →