NXPH1

Across TCGA cell cohorts, NXPH1 mutation is significantly associated with the drug of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NXPH1-associated genes across cancer lineages are MK-1775, 630600, and 150412. Each is linked with NXPH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXPH1-to-partner and partner-to-NXPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MK-1775 grouped by NXPH1-low versus NXPH1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXPH1→partner) and Y-score (partner→NXPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MK-1775 →	+0.322	+2.646	.049	.047	3	1
LARGE_INTESTINE	630600 →	+0.653	+2.649	.036	.046	3	1
LARGE_INTESTINE	150412 →	+0.465	+2.777	.004	.038	2	1
LARGE_INTESTINE	TL-2-105 →	+0.545	+2.652	.004	.045	2	1
LARGE_INTESTINE	LIMK1 inhibitor BMS4 →	+0.370	+2.786	.040	.037	2	1
LARGE_INTESTINE	Dinaciclib →	+0.525	+2.646	.042	.047	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MK-1775 by NXPH1 expression — LARGE_INTESTINE

Explore this box plot interactively →