Across TCGA patient cohorts, NXPE2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NXPE2-associated genes across cancer lineages are Annexin-1, STAT3_pY705, and 14-3-3_beta. Each is linked with NXPE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXPE2-to-partner and partner-to-NXPE2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXPE2→partner) and Y-score (partner→NXPE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.411	+1.894	.047	.030	3	2
UCEC	STAT3_pY705 →	-0.281	-2.574	.006	.010	3	2
UCEC	14-3-3_beta →	-0.111	-1.979	.004	.030	3	1
UCEC	eIF4E →	+0.191	+3.700	.020	.001	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.354	+1.584	.035	.036	3	1
UCEC	Ku80 →	+0.224	+1.598	.015	.022	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

NXPE2 survival (RNA) · tumor vs normal (RNA) · all NXPE2 data types