NXNL2

Across TCGA patient cohorts, NXNL2 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible NXNL2-associated genes across cancer lineages are TRAJ36, RNU6-247P, and RNU6-905P. Each is linked with NXNL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXNL2-to-partner and partner-to-NXNL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ36 grouped by NXNL2-low versus NXNL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXNL2→partner) and Y-score (partner→NXNL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ36 →	+1.222	+4.606	<.001	.004	3	1
SKCM	RNU6-247P →	+0.376	+4.979	.004	.009	3	1
SKCM	RNU6-905P →	+0.396	+5.513	<.001	.004	3	1
SKCM	SC4MOP →	+0.057	+5.680	.009	.003	3	1
SKCM	RPL7P3 →	+0.139	+5.362	<.001	.005	3	1
SKCM	LINC01392 →	+0.138	+5.224	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

TRAJ36 by NXNL2 expression — UCEC

Explore this box plot interactively →