NXF4

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, NXF4 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NXF4-associated genes across cancer lineages are JNK2, p38-MAPK_pT180_Y182, and Annexin-1. Each is linked with NXF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXF4-to-partner and partner-to-NXF4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXF4→partner) and Y-score (partner→NXF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECJNK2 →+0.248+2.331<.001<.00132
UCECp38-MAPK_pT180_Y182 →-0.328-1.188.019.02832
UCECAnnexin-1 →+0.620+2.267<.001<.00132
UCECSTAT3_pY705 →-0.294-1.201<.001.02832
UCECCyclin-B1 →+0.465+1.584.007.03232
UCEC14-3-3_beta →-0.084-2.388.006.00231
Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration