NXF3

Across TCGA patient cohorts, NXF3 mutation is significantly associated with the RNA expression of many other genes, with 5,072 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NXF3-associated genes across cancer lineages are KLHL29, UQCRC1, and CORO2B. Each is linked with NXF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NXF3-to-partner and partner-to-NXF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL29 grouped by NXF3-low versus NXF3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXF3→partner) and Y-score (partner→NXF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KLHL29 →	-0.682	-3.807	.001	<.001	3	3
UCEC	UQCRC1 →	+0.373	+3.018	<.001	<.001	3	3
SKCM	CORO2B →	-1.166	-2.483	.005	.001	3	3
UCEC	FCER1A →	-0.800	-2.584	<.001	<.001	3	3
SKCM	SOX9 →	-1.126	-2.296	.003	.005	3	3
UCEC	LINC02519 →	-0.184	-1.924	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,072 associations by consensus.

KLHL29 by NXF3 expression — LUAD

Explore this box plot interactively →