NXF3

Across TCGA patient cohorts, NXF3 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NXF3-associated genes across cancer lineages are PCNA, eIF4E, and JNK_pT183_Y185. Each is linked with NXF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NXF3-to-partner and partner-to-NXF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by NXF3-low versus NXF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXF3→partner) and Y-score (partner→NXF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.213	+2.247	.002	.001	3	3
SKCM	eIF4E →	+0.188	+3.087	.007	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.163	-2.169	.002	.003	3	2
UCEC	p21 →	+0.142	+2.906	.020	.001	3	2
UCEC	p70-S6K_pT389 →	-0.185	-2.415	.002	.002	3	2
SKCM	eEF2 →	+0.346	+4.169	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

PCNA by NXF3 expression — UCEC

Explore this box plot interactively →