NXF3

Across TCGA cell cohorts, NXF3 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NXF3-associated genes across cancer lineages are MUC7, DIRC1, and ZNF804B. Each is linked with NXF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXF3-to-partner and partner-to-NXF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MUC7 grouped by NXF3-low versus NXF3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXF3→partner) and Y-score (partner→NXF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MUC7 →	+0.078	+3.115	<.001	.004	3	1
LARGE_INTESTINE	DIRC1 →	+0.002	+3.700	<.001	.009	3	1
LARGE_INTESTINE	ZNF804B →	+0.015	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	HMX3 →	+0.791	+3.531	<.001	.007	3	1
LARGE_INTESTINE	ELANE →	+0.270	+3.404	.002	.006	3	1
LUNG_SCLC	OR56A5 →	+0.187	+3.662	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MUC7 by NXF3 expression — LARGE_INTESTINE

Explore this box plot interactively →