NXF2B

Across TCGA pan-cancer cohorts, NXF2B RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of NXF2B’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where NXF2B RNA is repressed in tumor relative to normal tissue. In most cancer types NXF2B is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

LUSC, KICH, and KIRC are the cancer types where NXF2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NXF2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	−0.015	<.001	4	view →
KICH	All	II,III,IV	−0.005	.032	2	view →
KIRC	Male	All	−0.002	.010	2	view →
LUAD	All	II,III,IV	−0.017	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

NXF2B–LUSC

Open the LUSC breakdown →