NXF2

Across TCGA cell cohorts, NXF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 322 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible NXF2-associated GO terms across cancer lineages are Establishment of protein localization to organelle, RNA 3'-end processing, and Negative regulation of developmental growth. Each is linked with NXF2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NXF2-to-partner and partner-to-NXF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of protein localization to organelle grouped by NXF2-low versus NXF2-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NXF2→partner) and Y-score (partner→NXF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Establishment of protein localization to organelle →	+0.025	+1.060	.006	.008	3	4
CNS	RNA 3'-end processing →	+0.029	+1.050	.006	.009	3	3
CNS	Negative regulation of developmental growth →	-0.052	-1.351	<.001	.009	3	3
LUNG_SCLC	Positive regulation of DNA-templated transcription initiation →	+0.050	+1.288	.007	<.001	3	3
LUNG_SCLC	Production of molecular mediator of immune response →	+0.044	+1.179	.008	.001	3	3
LUNG_SCLC	Transcription initiation at RNA polymerase II promoter →	+0.045	+1.045	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 322 associations by consensus.

Establishment of protein localization to organelle by NXF2 expression — CNS

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