NVL

Across TCGA pan-cancer cohorts, NVL Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated NVL data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NVL Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NVL expression acts as an unfavorable survival marker.

HNSC, LUAD, and KIRP are the cancer types where NVL Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.150	0.661	.001	45	view →
LUAD	OS	Median	II,III,IV	0.053	0.751	<.001	36	view →
KIRP	OS	Median	All	0.129	0.708	<.001	11	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
LIHC	OS	Median	II,III,IV	0.226	0.769	.008	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

NVL–HNSC (OS)

Open the HNSC breakdown →