NVL

Across TCGA patient cohorts, NVL mutation is significantly associated with the RNA expression of many other genes, with 4,696 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NVL-associated genes across cancer lineages are EIF4A2P5, RNA5SP333, and BUB3. Each is linked with NVL in more than 2 cancer types. Because this analysis shows association rather than direction, both NVL-to-partner and partner-to-NVL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF4A2P5 grouped by NVL-low versus NVL-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NVL→partner) and Y-score (partner→NVL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EIF4A2P5 →	+0.029	+3.343	<.001	.004	3	3
LUAD	RNA5SP333 →	+0.226	+4.303	<.001	.009	3	3
UCEC	BUB3 →	+0.593	+2.584	<.001	<.001	3	3
UCEC	ELP6 →	+0.247	+2.024	.006	.007	3	3
UCEC	RRP36 →	+0.364	+2.021	<.001	<.001	3	3
KIRP	RNA5SP426 →	+0.284	+5.159	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,696 associations by consensus.

EIF4A2P5 by NVL expression — SKCM

Explore this box plot interactively →