NVL

Across TCGA patient cohorts, NVL mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NVL-associated genes across cancer lineages are MEK1, eIF4E, and Ku80. Each is linked with NVL in more than 2 cancer types. Because this analysis shows association rather than direction, both NVL-to-partner and partner-to-NVL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by NVL-low versus NVL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NVL→partner) and Y-score (partner→NVL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.439	+2.263	<.001	<.001	3	3
UCEC	eIF4E →	+0.141	+1.652	.042	.006	3	2
UCEC	Ku80 →	+0.211	+1.951	.006	<.001	3	2
UCEC	p70-S6K →	+0.136	+1.604	.032	.021	3	2
UCEC	Caspase-7-cleavedD198 →	+0.606	+2.115	.001	.016	3	2
UCEC	Cyclin-B1 →	+0.370	+2.115	.045	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

MEK1 by NVL expression — UCEC

Explore this box plot interactively →