NVL

Across TCGA cell cohorts, NVL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,313 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NVL-associated GO terms across cancer lineages are Regulation of sister chromatid cohesion, Nuclear pore organization, and Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Each is linked with NVL in more than 16 cancer types. Because this analysis shows association rather than direction, both NVL-to-partner and partner-to-NVL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of sister chromatid cohesion grouped by NVL-low versus NVL-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NVL→partner) and Y-score (partner→NVL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of sister chromatid cohesion →	+0.127	+0.736	.002	.002	3	17
BONE	Nuclear pore organization →	+0.218	+1.186	<.001	<.001	3	16
BONE	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.166	+0.903	.001	.003	3	16
UPPER_AERODIGESTIVE_TRACT	Nuclear transport →	+0.068	+0.740	.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Nucleocytoplasmic transport →	+0.068	+0.740	.001	<.001	3	15
STOMACH	Establishment of protein localization to endoplasmic reticulum membrane →	+0.149	+0.818	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,313 associations by consensus.

Regulation of sister chromatid cohesion by NVL expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →