NVL

Across TCGA cell cohorts, NVL mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NVL-associated genes across cancer lineages are GABRA4, TXNDC8, and CSN1S1. Each is linked with NVL in more than 1 cancer types. Because this analysis shows association rather than direction, both NVL-to-partner and partner-to-NVL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GABRA4 grouped by NVL-low versus NVL-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NVL→partner) and Y-score (partner→NVL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GABRA4 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	TXNDC8 →	+0.016	+4.906	<.001	.006	3	1
BLOOD_Leukemia	CSN1S1 →	+0.258	+2.870	<.001	.005	3	1
BLOOD_Leukemia	DSC1 →	+0.109	+2.929	.006	.009	3	1
BLOOD_Leukemia	CSH1 →	+0.039	+3.076	<.001	.002	3	1
BLOOD_Leukemia	ASTN1 →	+0.163	+3.379	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

GABRA4 by NVL expression — OESOPHAGUS

Explore this box plot interactively →