NUS1

Across TCGA pan-cancer cohorts, NUS1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NUS1 data layer compared with 30 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NUS1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NUS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where NUS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	II,III,IV	0.559	0.913	.015	10	view →
LUAD	OS	Quartile	II,III,IV	0.293	0.705	.017	10	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.853	.025	7	view →
UCEC	DFS	Tertile	All	0.713	1.000	.020	6	view →
PDAC	DFS	Median	All	0.621	0.844	.024	4	view →
LSCC	OS	Median	II,III,IV	1.000	0.880	.023	4	view →
GBM	OS	Median	All	0.412	0.591	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NUS1–CCRCC (OS)

Open the CCRCC breakdown →