NUS1

Across TCGA patient cohorts, NUS1 mutation is significantly associated with the RNA expression of many other genes, with 2,027 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUS1-associated genes across cancer lineages are BTBD10, IMMP1L, and PTPRJ. Each is linked with NUS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUS1-to-partner and partner-to-NUS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BTBD10 grouped by NUS1-low versus NUS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUS1→partner) and Y-score (partner→NUS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BTBD10 →	+0.455	+3.491	.005	.002	3	1
UCEC	IMMP1L →	+0.487	+4.180	<.001	<.001	3	1
UCEC	PTPRJ →	+0.718	+3.483	.001	.002	3	1
UCEC	CAPN5 →	-0.736	-2.382	.002	.003	3	1
UCEC	MTA2 →	+0.488	+3.627	<.001	.001	3	1
UCEC	CCDC15 →	+0.405	+3.475	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,027 associations by consensus.

BTBD10 by NUS1 expression — UCEC

Explore this box plot interactively →