NUS1

Across TCGA cell cohorts, NUS1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NUS1-associated genes across cancer lineages are NPHS2, MSGN1, and C12orf40. Each is linked with NUS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUS1-to-partner and partner-to-NUS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPHS2 grouped by NUS1-low versus NUS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUS1→partner) and Y-score (partner→NUS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NPHS2 →	+0.082	+4.029	.003	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.061	+3.930	.007	.003	3	1
LARGE_INTESTINE	C12orf40 →	+0.011	+5.099	<.001	<.001	3	1
LARGE_INTESTINE	TFDP3 →	+0.024	+4.196	<.001	.002	3	1
LARGE_INTESTINE	TAFA1 →	+0.329	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	CD300LD →	+0.076	+3.793	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

NPHS2 by NUS1 expression — LARGE_INTESTINE

Explore this box plot interactively →