NUPR1

Across TCGA cell cohorts, NUPR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,664 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NUPR1-associated GO terms across cancer lineages are Positive regulation of oxidative phosphorylation, Negative regulation of autophagosome assembly, and Regulation of type B pancreatic cell proliferation. Each is linked with NUPR1 in more than 12 cancer types. Because this analysis shows association rather than direction, both NUPR1-to-partner and partner-to-NUPR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of oxidative phosphorylation grouped by NUPR1-low versus NUPR1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NUPR1→partner) and Y-score (partner→NUPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of oxidative phosphorylation →	+0.214	+4.069	.006	<.001	2	13
SOFT_TISSUE	Negative regulation of autophagosome assembly →	+0.149	+3.131	<.001	<.001	3	11
OVARY	Regulation of type B pancreatic cell proliferation →	+0.393	+2.819	.001	<.001	3	11
LIVER	Positive regulation of cellular respiration →	+0.225	+2.905	<.001	<.001	3	9
BONE	Regulation of amino acid biosynthetic process →	+0.228	+5.076	<.001	<.001	3	8
BONE	Response to endoplasmic reticulum stress →	+0.061	+3.707	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,664 associations by consensus.

Positive regulation of oxidative phosphorylation by NUPR1 expression — LIVER

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