NUP93

Across TCGA pan-cancer cohorts, NUP93 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NUP93 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NUP93 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NUP93 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where NUP93 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.636	0.954	.001	61	view →
PDAC	DFS	Tertile	All	0.322	0.557	.003	34	view →
LUAD	DFS	Median	II,III,IV	0.762	0.341	.004	28	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.433	<.001	23	view →
HNSC	OS	Median	All	0.782	0.908	.006	18	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NUP93–CCRCC (OS)

Open the CCRCC breakdown →