NUP93

Across TCGA patient cohorts, NUP93 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP93-associated genes across cancer lineages are 14-3-3_beta, eEF2, and Tuberin. Each is linked with NUP93 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP93-to-partner and partner-to-NUP93 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by NUP93-low versus NUP93-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP93→partner) and Y-score (partner→NUP93) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.070	-1.880	.038	.014	3	2
UCEC	eEF2 →	+0.357	+2.000	.002	.029	3	2
UCEC	Tuberin →	+0.248	+1.321	.005	.029	3	2
UCEC	eIF4E →	+0.157	+2.906	.026	.001	3	1
UCEC	A-Raf_pS299 →	-0.092	-2.459	.021	.018	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.424	+2.125	.012	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

14-3-3_beta by NUP93 expression — UCEC

Explore this box plot interactively →