NUP88

Across TCGA pan-cancer cohorts, NUP88 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NUP88 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NUP88 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NUP88 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where NUP88 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.595	0.883	<.001	89	view →
LUAD	DFS	Tertile	All	0.816	0.338	<.001	54	view →
LSCC	DFS	Tertile	II,III,IV	0.941	0.517	.004	23	view →
HNSC	DFS	Quartile	All	0.114	1.000	.017	20	view →
COAD	DFS	Median	II,III,IV	1.000	0.884	.025	12	view →
PDAC	DFS	Median	All	0.213	0.427	.008	9	view →
GBM	OS	Quartile	All	0.582	0.344	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NUP88–CCRCC (DFS)

Open the CCRCC breakdown →