NUP88

Across TCGA cell cohorts, NUP88 mutation is significantly associated with the drug of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NUP88-associated genes across cancer lineages are Sinularin, Quizartinib, and BDF00022089a. Each is linked with NUP88 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP88-to-partner and partner-to-NUP88 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sinularin grouped by NUP88-low versus NUP88-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP88→partner) and Y-score (partner→NUP88) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Sinularin →	+0.380	+2.777	.015	.038	2	2
LARGE_INTESTINE	Quizartinib →	+0.366	+2.652	.022	.045	3	1
LARGE_INTESTINE	BDF00022089a →	+0.320	+2.649	.039	.046	2	1
LARGE_INTESTINE	IWP-2 →	+0.301	+2.893	.023	.034	1	1
LARGE_INTESTINE	BDILV000379a →	+0.370	+2.649	.015	.046	1	1
LARGE_INTESTINE	LGK974 →	+0.509	+2.646	.001	.047	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Sinularin by NUP88 expression — LARGE_INTESTINE

Explore this box plot interactively →