NUP85

Across TCGA pan-cancer cohorts, NUP85 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NUP85 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NUP85 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NUP85 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where NUP85 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.726	0.947	<.001	80	view →
PDAC	OS	Tertile	II,III,IV	0.348	0.777	<.001	67	view →
LSCC	DFS	Quartile	II,III,IV	0.929	0.361	.002	19	view →
HNSC	OS	Quartile	All	0.745	0.909	.016	16	view →
UCEC	DFS	Tertile	All	0.781	0.969	.010	10	view →
GBM	DFS	Tertile	All	0.452	0.227	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NUP85–CCRCC (OS)

Open the CCRCC breakdown →