NUP85

Across TCGA cell cohorts, NUP85 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NUP85-associated genes across cancer lineages are STARD6, IGFL3, and KRTAP10-2. Each is linked with NUP85 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP85-to-partner and partner-to-NUP85 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STARD6 grouped by NUP85-low versus NUP85-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP85→partner) and Y-score (partner→NUP85) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	STARD6 →	+0.098	+3.466	<.001	.005	3	1
LARGE_INTESTINE	IGFL3 →	+0.323	+3.541	<.001	.004	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.050	+3.257	<.001	.001	3	1
LARGE_INTESTINE	DAZ4 →	+0.123	+3.240	.004	.004	3	1
LARGE_INTESTINE	CCDC195 →	+0.039	+2.882	<.001	.005	3	1
BREAST	IFNA2 →	+0.022	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

STARD6 by NUP85 expression — LARGE_INTESTINE

Explore this box plot interactively →