NUP54

Across TCGA patient cohorts, NUP54 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP54-associated genes across cancer lineages are C-Raf, GAPDH, and MEK1. Each is linked with NUP54 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP54-to-partner and partner-to-NUP54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by NUP54-low versus NUP54-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP54→partner) and Y-score (partner→NUP54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.166	+2.584	.005	.010	3	2
UCEC	GAPDH →	+0.521	+2.999	.018	.035	3	1
UCEC	MEK1 →	+0.429	+2.321	.004	.006	3	1
UCEC	p62 Lck ligand →	+0.331	+2.331	.013	.019	3	1
UCEC	PCNA →	+0.332	+3.584	<.001	.002	3	1
UCEC	PDCD4 →	-0.575	-3.169	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

C-Raf by NUP54 expression — UCEC

Explore this box plot interactively →