NUP50

Across TCGA pan-cancer cohorts, NUP50 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NUP50 data layer compared with 28 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NUP50 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NUP50 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, ACC, and SKCM are the cancer types where NUP50 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.002	0.746	<.001	24	view →
ACC	DFS	Median	All	0.195	0.748	.003	9	view →
SKCM	OS	Median	III,IV	0.204	0.708	<.001	6	view →
UCEC	DFS	Median	All	0.759	0.634	.026	4	view →
COAD	OS	Median	II,III,IV	0.556	0.850	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NUP50–HNSC (OS)

Open the HNSC breakdown →