NUP50

Across TCGA pan-cancer cohorts, NUP50 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NUP50 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NUP50 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NUP50 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where NUP50 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.496	0.876	.001	28	view →
PDAC	DFS	Median	All	0.920	0.659	.012	14	view →
CCRCC	OS	Median	All	0.909	1.000	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NUP50–HNSC (DFS)

Open the HNSC breakdown →