NUP50

Across TCGA patient cohorts, NUP50 mutation is significantly associated with the RNA expression of many other genes, with 3,074 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP50-associated genes across cancer lineages are PHF5A, USP14, and KCTD9. Each is linked with NUP50 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP50-to-partner and partner-to-NUP50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF5A grouped by NUP50-low versus NUP50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP50→partner) and Y-score (partner→NUP50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHF5A →	+0.470	+2.765	<.001	<.001	3	2
UCEC	USP14 →	+0.387	+1.898	.001	.001	3	2
UCEC	KCTD9 →	+0.615	+2.470	<.001	<.001	3	2
UCEC	C1QBP →	+0.452	+1.736	<.001	<.001	3	2
UCEC	GRPEL1 →	+0.473	+2.459	<.001	<.001	3	2
UCEC	SLCO1B3 →	+0.361	+2.063	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,074 associations by consensus.

PHF5A by NUP50 expression — UCEC

Explore this box plot interactively →