NUP50

Across TCGA patient cohorts, NUP50 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP50-associated genes across cancer lineages are ASNS, MEK1, and ATM. Each is linked with NUP50 in more than 2 cancer types. Because this analysis shows association rather than direction, both NUP50-to-partner and partner-to-NUP50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by NUP50-low versus NUP50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP50→partner) and Y-score (partner→NUP50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.440	+1.353	<.001	.015	3	3
UCEC	MEK1 →	+0.378	+2.115	.001	<.001	3	2
UCEC	ATM →	-0.316	-1.986	.027	.029	3	2
UCEC	14-3-3_beta →	-0.103	-2.143	.001	.002	3	1
UCEC	EGFR_pY1068 →	-0.241	-3.169	.002	<.001	3	1
UCEC	EGFR →	-0.114	-1.584	.023	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ASNS by NUP50 expression — UCEC

Explore this box plot interactively →