NUP50

Across TCGA cell cohorts, NUP50 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,567 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NUP50-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Microtubule organizing center organization, and Positive regulation of T-helper 17 cell lineage commitment. Each is linked with NUP50 in more than 17 cancer types. Because this analysis shows association rather than direction, both NUP50-to-partner and partner-to-NUP50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by NUP50-low versus NUP50-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP50→partner) and Y-score (partner→NUP50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of chromosome condensation →	+0.175	+0.863	<.001	<.001	3	18
OESOPHAGUS	Microtubule organizing center organization →	+0.073	+0.756	.003	.002	3	16
KIDNEY	Positive regulation of T-helper 17 cell lineage commitment →	+0.244	+1.084	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Meiotic chromosome condensation →	+0.160	+0.664	.001	.007	2	16
BONE	DNA-templated DNA replication maintenance of fidelity →	+0.102	+0.796	<.001	<.001	3	15
SOFT_TISSUE	Regulation of chromosome condensation →	+0.215	+0.973	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,567 associations by consensus.

Negative regulation of chromosome condensation by NUP50 expression — OESOPHAGUS

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