NUP42

Across TCGA pan-cancer cohorts, NUP42 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NUP42 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NUP42 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NUP42 expression acts as an unfavorable survival marker, although some lineages such as LUAD and OV show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where NUP42 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.972	0.861	.003	37	view →
PDAC	OS	Quartile	II,III,IV	0.274	0.467	.033	10	view →
HNSC	DFS	Quartile	III,IV	0.610	0.942	.003	10	view →
UCEC	DFS	Median	III,IV	0.499	0.900	.025	8	view →
OV	DFS	Tertile	All	1.000	0.627	.038	4	view →
CCRCC	OS	Median	All	0.715	1.000	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NUP42–LUAD (DFS)

Open the LUAD breakdown →