NUP42

Across TCGA patient cohorts, NUP42 mutation is significantly associated with the RNA expression of many other genes, with 727 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP42-associated genes across cancer lineages are MIR3689C, LINC02647, and USP17L8. Each is linked with NUP42 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP42-to-partner and partner-to-NUP42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3689C grouped by NUP42-low versus NUP42-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP42→partner) and Y-score (partner→NUP42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR3689C →	+0.996	+8.055	<.001	.007	3	2
BRCA	LINC02647 →	+0.118	+7.731	<.001	.009	3	2
BRCA	USP17L8 →	+0.019	+7.731	<.001	.009	3	2
BLCA	AIPL1 →	+0.129	+2.840	<.001	.009	3	2
BLCA	DEFB131A →	+0.078	+4.307	<.001	.005	3	2
UCEC	RNU7-81P →	+0.416	+3.579	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 727 associations by consensus.

MIR3689C by NUP42 expression — BRCA

Explore this box plot interactively →