NUP37

Across TCGA patient cohorts, NUP37 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP37-associated genes across cancer lineages are EGFR_pY1068, MEK1, and p62 Lck ligand. Each is linked with NUP37 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP37-to-partner and partner-to-NUP37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NUP37-low versus NUP37-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP37→partner) and Y-score (partner→NUP37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.321	-3.700	.006	.001	3	1
UCEC	MEK1 →	+0.401	+2.584	.018	.011	3	1
UCEC	p62 Lck ligand →	+0.534	+3.700	<.001	.001	3	1
UCEC	PCNA →	+0.202	+2.999	.044	.035	3	1
UCEC	PDCD4 →	-0.643	-3.169	.003	.018	3	1
UCEC	Shc_pY317 →	-0.146	-3.000	.039	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by NUP37 expression — UCEC

Explore this box plot interactively →