Across TCGA pan-cancer cohorts, NUP35P2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of NUP35P2’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where NUP35P2 RNA is repressed in tumor relative to normal tissue. In most cancer types NUP35P2 is over-expressed in tumor, although a few such as BRCA and LUSC show the opposite, repressed pattern.
BRCA and LUSC are the cancer types where NUP35P2 tumor–normal differential expression is most reproducible.